How does Breo Ellipta Work?

The pharmacological effect of the active substances? 2-adrenergic agonists, including vilanterol triphenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyzes the transformation of adenosine triphosphate (ATP) to adenosine monophosphate – 3 ‘, 5’ cyclic (cyclic AMP). The increase in cyclic AMP levels results in relaxation of the bronchial smooth muscle and inhibition of the release of mediators of immediate hypersensitivity of cells, especially mast cells.

Molecular interactions between corticosteroids and LABAs occur, whereby steroids activate the? 2 receptor gene increasing the number of receptors and sensitivity, and LABAs prepare the glucocorticoid receptor for steroid-dependent activation and increase cellular nuclear translocation. These synergistic interactions are reflected in increased anti-inflammatory activity, which has been demonstrated in vitro and in vivo in a variety of inflammatory cells relevant to the pathophysiology of asthma and COPD. In peripheral blood mononuclear cells from subjects with COPD, a greater anti-inflammatory effect was observed in the presence of the combination with fluticasone furoate/vilanterol compared to fluticasone furoate monotherapy at concentrations reached with clinical doses. The potential anti-inflammatory effect of the LABA component was similar to that obtained with other ICS / LABA combinations.

How do I use Breo Ellipta ?

• This medicine comes in a foil tray. Peel back the lid to open the tray.

• Slide the inhaler cover down until you hear a clicking sound. The inhaler is now ready to use. Do not open the cover of the inhaler until you are ready to use it. If you open and close the inhaler without inhaling the dose, you will lose the medicine.

• Put the mouthpiece between your lips and close your lips around the mouthpiece. Do not block the air vent with your fingers.

• Breathe in through your mouth as deeply as you can until you have taken a full deep breath. Do not breathe through your nose.

• Hold your breath and remove the mouthpiece from your mouth. Continue holding your breath as long as you can up to 3 or 4 seconds before breathing out slowly. This gives the medicine time to settle in your airways and lungs.

• When you are finished, you may clean the mouthpiece with a dry tissue, if needed, before closing the inhaler cover.

• The inhaler has a window that shows the number of doses that are left. This tells you when you are getting low on medicine. When the inhaler has less than 10 doses left, the left half of the counter will show up in red to remind you to refill your prescription.

Rinsing your mouth with water after each dose may help prevent hoarseness, throat irritation, and infection in the mouth. However, do not swallow the water after rinsing.