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Buy Daliresp Online | What is Roflumilast?

Buy Daliresp Online | Roflumilast is a medication that is used in the treatment of chronic obstructive pulmonary disease (COPD). It is a selective phosphodiesterase-4 (PDE-4) inhibitor, which means it works by inhibiting an enzyme called phosphodiesterase-4 in the lungs, leading to relaxation of the airway smooth muscles and reduction of inflammation.

Roflumilast is available in tablet form and is typically taken orally once daily. It is indicated for use in patients with severe COPD associated with chronic bronchitis and a history of exacerbations (flare-ups) who have not responded well to other treatments. It is not intended to be used as a rescue medication for acute breathing problems, but rather as a maintenance treatment to help reduce the frequency of exacerbations in patients with severe COPD.

Roflumilast is a prescription medication, and its use should be guided by a qualified healthcare professional. It may have potential side effects, including nausea, diarrhea, weight loss, headache, and psychiatric symptoms such as anxiety and depression. It is important to follow the prescribed dosage and instructions provided by the healthcare provider and report any concerning side effects promptly.

How does Roflumilast work?

Roflumilast works by inhibiting an enzyme called phosphodiesterase-4 (PDE-4), which is found predominantly in inflammatory cells in the lungs. PDE-4 is responsible for breaking down cyclic AMP (cAMP), a molecule that plays a role in regulating inflammation and smooth muscle tone in the airways.

By inhibiting PDE-4, roflumilast increases the levels of cAMP in the lungs. This leads to several effects that help in the treatment of chronic obstructive pulmonary disease (COPD):

1. Reduction of inflammation: Increased cAMP levels inhibit the production of inflammatory mediators, such as cytokines and chemokines, which are involved in the inflammatory response in the airways. This can help reduce the inflammation and swelling of the airways, which is a characteristic feature of COPD.
2. Relaxation of airway smooth muscles: Increased cAMP levels also promote relaxation of the smooth muscles that surround the airways, leading to bronchodilation. This helps to widen the airways, making it easier for air to flow in and out of the lungs, which can relieve symptoms of COPD like wheezing and shortness of breath.
3. Suppression of immune cell activity: PDE-4 inhibitors like roflumilast can also reduce the activity of immune cells, such as neutrophils and eosinophils, which are involved in the inflammatory response in COPD. This can help further decrease the inflammation in the airways.

How to take Roflumilast?

Roflumilast is available in tablet form and is typically taken orally once daily. Here are some general guidelines for taking roflumilast:

1. Follow the prescribed dosage: Roflumilast should be taken exactly as prescribed by your healthcare provider. The recommended dosage for roflumilast is usually one tablet (either 250 mcg or 500 mcg strength) taken orally once daily, with or without food. Do not take more or less than the prescribed dose, and do not stop taking roflumilast without consulting your healthcare provider.
2. Take it at the same time each day: It is recommended to take roflumilast at the same time each day to maintain a consistent level of the medication in your system. This can help ensure its effectiveness in managing your COPD symptoms.
3. Swallow the tablet whole: Do not crush, chew, or break the roflumilast tablet. Swallow it whole with water. If you have difficulty swallowing tablets, talk to your healthcare provider for alternative options.
4. Avoid alcohol and grapefruit juice: Alcohol and grapefruit juice may interact with roflumilast and increase the risk of side effects. It’s best to avoid alcohol and grapefruit juice while taking roflumilast, or follow your healthcare provider’s instructions regarding their use.
5. Continue other COPD medications as prescribed: Roflumilast is typically used as a maintenance treatment for COPD and is not intended to replace other COPD medications, such as short-acting bronchodilators or inhaled corticosteroids. Continue taking other COPD medications as prescribed by your healthcare provider, unless otherwise instructed.
6. Report any side effects or concerns: If you experience any side effects or have concerns while taking roflumilast, such as nausea, diarrhea, weight loss, headache, or changes in mood or behavior, promptly report them to your healthcare provider for evaluation and guidance.