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Buy Entresto  Online | what is Sacubitril/Valsartan?

Buy Entresto  Online |  Sacubitril/Valsartan is a medication that is used to treat heart failure. It is a combination drug that contains two active ingredients: sacubitril and valsartan. Sacubitril is a neprilysin inhibitor, which works by blocking the action of an enzyme called neprilysin, leading to increased levels of certain substances that can help relax blood vessels and reduce the workload on the heart. Valsartan is an angiotensin II receptor blocker (ARB), which works by blocking the effects of a hormone called angiotensin II, which can constrict blood vessels and increase blood pressure. Together, sacubitril and valsartan work to help improve heart function and reduce symptoms of heart failure in patients who have reduced ejection fraction (a measure of how much blood the heart pumps out with each beat) and are already taking other heart failure medications, but still have persistent symptoms. Sacubitril/Valsartan is available in tablet form and is usually prescribed by a healthcare provider. It is also commonly known by its brand name, Entresto. As with any medication, it is important to take Sacubitril/Valsartan exactly as prescribed and to follow your healthcare provider’s instructions for its use.

How does Sacubitril/Valsartan work ?

Sacubitril/Valsartan is a combination medication that works by targeting two different mechanisms to help improve heart function in patients with heart failure.

1. Sacubitril: Sacubitril is a neprilysin inhibitor, which works by blocking the action of an enzyme called neprilysin. Neprilysin is responsible for breaking down certain substances in the body, including natriuretic peptides, which are naturally occurring hormones that help relax blood vessels and reduce the workload on the heart. By inhibiting neprilysin, sacubitril increases the levels of natriuretic peptides, leading to vasodilation (widening of blood vessels) and decreased sodium and fluid retention, which can help reduce the strain on the heart and improve heart function.
2. Valsartan: Valsartan is an angiotensin II receptor blocker (ARB), which works by blocking the effects of a hormone called angiotensin II. Angiotensin II is a potent vasoconstrictor, which means it constricts blood vessels and increases blood pressure. By blocking the effects of angiotensin II, valsartan helps to relax blood vessels, reduce blood pressure, and decrease the workload on the heart, which can improve heart function in patients with heart failure.

The combination of sacubitril and valsartan in Sacubitril/Valsartan is specifically designed to target these two pathways simultaneously, resulting in a dual action that can help improve heart function, reduce symptoms of heart failure, and potentially reduce the risk of hospitalization for heart failure in patients with reduced ejection fraction who are already taking other heart failure medications. However, it’s important to note that Sacubitril/Valsartan should only be used as prescribed by a healthcare provider, and the dosage and usage instructions should be followed carefully.

How to take Sacubitril/Valsartan ?

Sacubitril/Valsartan should be taken exactly as prescribed by your healthcare provider. It is usually available in tablet form and is typically taken by mouth. Here are some general guidelines on how to take Sacubitril/Valsartan:

1. Follow the prescribed dosage: Take Sacubitril/Valsartan exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking it without consulting your healthcare provider first.
2. Take it with or without food: Sacubitril/Valsartan can be taken with or without food. However, it’s important to take it consistently the same way each time, either with food or without food, as food can affect its absorption.
3. Avoid missing doses: Try to take Sacubitril/Valsartan at the same time(s) each day to maintain a consistent level of the medication in your bloodstream. If you do miss a dose, take it as soon as you remember, unless it’s close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed dose.
4. Do not crush or chew tablets: Sacubitril/Valsartan tablets should be swallowed whole with water and should not be crushed or chewed, as it may alter the effectiveness of the medication.
5. Follow additional instructions: Your healthcare provider may provide you with additional instructions based on your specific condition and medical history. Be sure to follow all instructions provided, including any dietary restrictions, activity limitations, or other precautions.
6. Do not stop without consulting your healthcare provider: Do not stop taking Sacubitril/Valsartan without consulting your healthcare provider first, even if you feel better. Suddenly stopping the medication can worsen your heart failure symptoms. Your healthcare provider will determine the appropriate treatment plan for you, which may include gradually tapering off the medication if needed.
7. Inform your healthcare provider of other medications: Inform your healthcare provider of all other medications, supplements, or herbal products you are taking, as Sacubitril/Valsartan may interact with other medications, and adjustments may be needed.

It’s crucial to follow your healthcare provider’s instructions carefully when taking Sacubitril/Valsartan or any other medication to ensure its safe and effective use. If you have any questions or concerns about how to take Sacubitril/Valsartan, consult your healthcare provider for guidance.